|
 UltraClear
Sustain
Gastrointestinal Support Program
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UltraClear SUSTAIN®
Monograph
UltraClear SUSTAIN is a fortified, powdered
beverage mix designed to provide nutritional support for gastrointestinal
function. UltraClear SUSTAIN provides nutrients required by the
gastrointestinal mucosal cells for cell differentiation, growth and
function, along with prebiotic nutrients to nutritionally support the
proliferation of friendly bacteria. UltraClear SUSTAIN is often used as
nutritional support for the Repair and Reinoculate phases of a 4R™
gastrointestinal support program. (The four "Rs" refer to
Remove, Replace, Reinoculate, and Repair.)
4R Program
Remove: Refers to the removal of any gastrointestinal parasites and/or
undesirable (pathogenic) bacteria or fungi that may be present and
contributing to dysfunction and/or abnormal symptoms. Remove also refers
to the removal from the diet of allergens and intolerant foods and
substances.
Replace: Denotes the replacement of any digestive
factors (e.g., enzymes) the body may not be making, or which it may be
making in inadequate amounts.
Reinoculate: Refers to the reintroduction of
"friendly" or desirable gastrointestinal bacteria (probiotics).
UltraClear SUSTAIN contains special ingredients (the prebiotics FOS and
inulin) that nutritionally support the proliferation of desirable
bacteria.
Repair: Refers to the provision of nutrients
needed for the cellular repair and functioning of the gastrointestinal
mucosal cells.
UltraClear SUSTAIN is a vegetarian formula composed of a
blend of macro- and micronutrients and a rice protein base that is of
lower allergy potential than normal rice. It is suitable for individuals
with dairy, gluten, or soy hypersensitivities. UltraClear SUSTAIN may be
used in the initial phase of a metabolic detoxification program or
following the UltraClear® program to help maintain nutritional support
after detoxification.
Who would benefit from the use of
UltraClear SUSTAIN ?
UltraClear SUSTAIN is designed to nutritionally
support individuals with the following conditions:
 | Functional digestive disorders
| Irritable bowel syndrome
| Exposure to environmental toxins
| Conditions associated with dysbiosis
| Chronic fatigue syndrome with gastrointestinal
involvement
| Problems associated with "leaky gut
syndrome"
| Those with gastrointestinal microflora imbalance
following antibiotic therapy |
| | | | | |
Why should you recommend
UltraClear SUSTAIN?
| UltraClear SUSTAIN is free of dairy, lactose, wheat,
corn, gluten, egg, yeast, soy, artificial colors, and artificial
flavors, and it is suitable for inclusion in diets avoiding these
substances. |
| It contains the prebiotics fructooligosaccharides and
inulin to promote proliferation of favorable bacteria in the digestive
tract.6-8
|
| L-glutamine, pantothenic acid, zinc, and ascorbic
acid are included to nutritionally support gastrointestinal mucosal
repair.9-14
|
| It contains glutathione, N-acetylcysteine, cysteine,
and additional antioxidants to nutritionally support detoxification
activity. |
Features:
| 220 calories per serving when mixed in water |
| 58 percent of calories from carbohydrate (rice syrup
solids, rice protein concentrate, inulin, and fructooligosaccharides) |
| 27 percent of calories from patented low-allergy rice
protein concentrate augmented with the first and second limiting amino
acids for increased biological value |
| 15 percent of calories from fat as medium-chain
triglycerides (MCT) and canola oil |
| Formulated to provide nutritional support for repair
and regeneration of gastrointestinal mucosa |
| Contains the prebiotic nutrients
fructooligosaccharides (FOS) and inulin |
| Does not contain gluten, wheat, corn, yeast, soy,
egg, dairy, stimulants, artificial coloring, artificial flavoring, or
animal products |
| Mixes easily with water or juice |
Key Ingredients:
| Low-allergy-potential, fortified, rice protein
concentrate: The rice protein concentrate is produced by a special
patented process.1
The resulting rice protein concentrate has been shown by competition
ELISA assays to be of lower allergy potential than normal rice.2
This patented rice protein concentrate is fortified with the first and
second limiting amino acids threonine and lysine, resulting in a
complete, high-quality, and easily digestible vegetable protein.3
|
| Rice flour: The rice flour is a specially
processed, low-allergy-potential rice flour. Although rice is
generally considered a low-allergy-potential food, several recent
studies have suggested that rice allergy may be increasing. The
processing technique used to prepare the rice flour has been shown by
competition ELISA assays to result in a flour that is of lower allergy
potential than normal rice flour.2
The rice flour also has a higher amylose content than the rice flour
used in the original formulation of UltraClear SUSTAIN. Research has
shown that rice varieties that contain a higher proportion of amylose
may have a slower rate of digestion and produce lower glycemic and
insulin responses.4
More recent research in eight healthy human subjects has shown that
high-amylose varieties of rice products have a lower glycemic index
(GI) than normal amylose varieties and are potentially useful in
low-GI diets.5
|
| Fructooligosaccharides (FOS) and inulin: The
normal intestinal microflora in humans provides protection against
infections caused by pathogenic microorganisms, preserves intestinal
integrity, provides short-chain fatty acids (SCFAs) as fuel for
colonocytes, and supports intestinal immunity.6
Studies have shown that orally given antibiotics may cause alterations
in the intestinal ecosystem and, as a result, the integrity of
gastrointestinal functions.7
FOS and inulin are naturally occurring oligosaccharides that resist
hydrolysis by human digestive enzymes and are selectively utilized by
beneficial intestinal microflora, such as Bifidobacteria. When
beneficial intestinal microflora consume inulin they produce SCFAs,
which are preferred fuel for gut mucosal cells.
 | Consumption of FOS and inulin have been shown to
enhance the intestinal population of Bifidobacteria, improve
consistency of stools, enhance lipid metabolism, increase SCFA
production, and decrease fecal pH.8
|
|
| L-glutamine: The gastrointestinal tract
mucosal cells (enterocytes), lymphocytes, and macrophages use
glutamine as a preferred respiratory fuel.9,10
Because of its role in numerous protein-related regulatory functions,
glutamine is proposed as a modulator of the general protein catabolic
response to stress. Since glutamine breaks down fairly rapidly in
solution, any glutamine-containing powdered product should be consumed
as soon as possible after it is mixed with liquids. |
| Pantothenic acid (vitamin B5): Pantothenic
acid has been shown to support protein synthesis. It is part of the
molecule coenzyme A, which functions in the cellular metabolism of
carbohydrates and fats to release energy.11
Research has shown that supplementation with pantothenic acid is
important in nutritional support for the normal healing process. There
is some suggestion that its effect is enhanced when it is combined
with ascorbic acid supplementation.12
|
| Ascorbic acid (vitamin C): Ascorbic acid is
well known for its role as a cofactor in the conversion of proline and
lysine to hydroxyproline and hydroxylysine respectively, both of which
are necessary for formation of collagen. Collagen is a major component
of connective tissues, and its synthesis is an essential component of
wound healing and tissue regeneration processes.13
Ascorbic acid is also a component of the antioxidant cascade, which
functions to quench free radicals and other reactive oxygen
intermediates that may be produced during the detoxification process. |
| Zinc (picolinate): Zinc is found in every
tissue in the body, and zinc metalloenzymes are found in every known
class of enzymes within the human body. Zinc functions primarily as a
cofactor for these enzymes, but it is also involved in the structure
of membranes and is essential for the replication of cells. Zinc
insufficiency is known to inhibit the healing processes. The
picolinate form of zinc is a complex of zinc and picolinic acid. The
advantage to metal picolinates is that they make the zinc, or any
other mineral attached to picolinic acid, more available for
absorption.14
|
| Vitamin A/beta-carotene: Beta-carotene, the
most abundant of the various carotenoids, is a precursor to vitamin A.
Unlike vitamin A, which can be toxic when consumed in excessive
amounts, beta-carotene appears to be nontoxic, except in cases of
excessive alcohol consumption and alcoholic liver disease. Among its
multiple functions within the biochemistry of the body’s systems,
vitamin A functions in the differentiation, growth, and function of
epithelial cells, including the gastrointestinal mucosal cells.15
It is also one of the components of the antioxidant cascade and has
been shown to function in the stimulation of T-helper cell activity
during the immune response. Thus, its dietary adequacy is essential to
the structural/barrier and immune defense of the GI mucosa. |
| Vitamin E (alpha-tocopherol): Vitamin E is
another important component of the antioxidant protective cascade. An
increased level of vitamin E above the RDA of 30 IU/day enhances
antioxidant support for the oxidative stress that is biochemically
generated during an infectious or inflammatory process.16
In rapidly proliferating tissues, it also functions in protecting
against free radical damage at active enzyme sites and DNA/RNA. |
| Glutathione, N-acetylcysteine, and cysteine:
These substances are considered accessory or, in some biochemical
situations, conditionally essential nutrients. Together, these
nutrients provide "fuel" or molecular support to the enzymes
that catalyze the detoxification processes. |
Ingredients:
Rice protein concentrate, rice syrup solids, rice flour, canola
oil, calcium citrate, medium-chain triglycerides, natural vanilla flavor,
magnesium citrate, fructooligosaccharides, dipotassium phosphate,
L-glutamine, vitamin A (beta-carotene, retinyl palmitate), dicalcium
phosphate, vitamin C (Ester-C®), vitamin E (d-alpha tocopheryl acetate),
calcium pantothenate, manganese gluconate, inulin, chromium polynicotinate
(ChromeMate® GTF ), L-threonine, L-lysine hydrochloride, selenomethionine,
zinc picolinate, niacinamide, L-cysteine hydrochloride, L-glutathione, N-acetylcysteine,
ferrous fumarate, pyridoxine hydrochloride, riboflavin, thiamin
hydrochloride, copper gluconate, folic acid, biotin, vitamin K, vitamin
D3, molybdenum amino acid chelate, and cyanocobalamin.
| Caloric Distribution |
Percent of Total Energy |
| Protein |
27% of calories |
| Carbohydrate |
58% of calories |
| Fat |
15% of calories |
| Nutritional
Information |
Amount
2 Scoops |
%
U.S. rda |
| |
(1 Serving) |
|
| Servings per container |
14 |
|
| Serving size |
60 g |
|
| Calories |
220 |
|
| Protein |
15 g |
|
| Carbohydrate |
32 g |
|
Complex
|
20 g |
|
Simple
|
12 g |
|
| Fat |
4 g |
|
| Cholesterol |
0 mg |
|
| Fiber |
2 g |
|
Vitamins:
| Nutritional
Information |
Amount
2 Scoops |
%
U.S. rda |
| |
(1 Serving) |
|
| † Vitamin A (retinyl
palmitate) |
2500 IU |
50% |
| † Beta-carotene |
2500 IU |
50% |
| Vitamin D3 |
100 IU |
25% |
| † Vitamin C (Ester-C®) |
102 mg |
170% |
| Vitamin K |
80 mcg |
100% |
| † Vitamin E (d-alpha
tocopheryl acetate & d-alpha tocopherol) |
51 IU |
170% |
| Vitamin B1(thiamin
hydrochloride) |
0.525 mg |
35% |
| Vitamin B2
(riboflavin) |
0.595 mg |
35% |
| Vitamin B3 (niacinamide) |
7 mg |
35% |
| Pantothenic acid
(calcium pantothenate) |
100 mg |
1000% |
| Vitamin B6 (pyridoxine
hydrochloride) |
0.7 mg |
35% |
| Vitamin B12 (cyanocobalamin) |
2.1 mcg |
35% |
| Biotin |
140 mcg |
35% |
| Folic acid |
105 mcg |
35% |
Minerals and Trace Elements:
| Nutritional
Information |
Amount
2 Scoops |
%
U.S. rda |
| |
(1 Serving) |
|
| Sodium |
20 mg |
|
| Potassium (phosphate
and iodide) |
300 mg |
|
| Calcium (citrate and
phosphate) |
275 mg |
30% |
| Iron (ferrous fumarate) |
3.6 mg |
20% |
| Phosphorous |
175 mg |
20% |
| Magnesium (citrate) |
125 mg |
30% |
| †Zinc (methionate) |
7.5 mg |
50% |
| †Copper (gluconate) |
0.5mg |
25% |
| †Manganese (gluconate) |
2 mg |
100% |
| Molybdenum (amino acid
chelate) |
50 mcg |
70% |
| Chromium (ChromeMate®
GTF) |
75 mcg |
60% |
| †Selenium (selenomethionine) |
50 mcg |
70% |
Accessory Nutrients:
| Nutritional
Information |
Amount
2 Scoops |
%
U.S. rda |
| |
(1 Serving) |
|
| D
†N-acetylcysteine |
5 mg |
** |
| D
†L-glutathione |
10 mg |
** |
| D
†L-cysteine |
5 mg |
** |
| D †L-glutamine |
500 mg |
** |
| Fructooligosaccharides |
2 g |
** |
| Inulin |
100 mg |
** |
Typical Amino Acid Profile:
| Nutritional
Information |
Amount
2 Scoops |
|
%
U.S. rda |
| |
(1 Serving) |
|
|
| Alanine |
770 mg |
|
** |
| Arginine |
1280 mg |
|
** |
| Aspartic acid |
1230 mg |
|
** |
| Cystine |
300 mg |
|
** |
| Glutamic acid |
2310 mg |
|
** |
| Glycine |
640 mg |
|
** |
| Histidine |
330 mg |
|
** |
| *Isoleucine |
580 mg |
|
** |
| *Leucine |
1180 mg |
|
** |
| *Lysine |
510 mg |
|
** |
| *Methionine |
330 mg |
|
** |
| *Phenylalanine |
710 mg |
|
** |
| Proline |
710 mg |
|
** |
| Serine |
770 mg |
|
** |
| *Threonine |
530 mg |
|
** |
| *Tryptophan |
180 mg |
|
** |
| Tyrosine |
720 mg |
|
** |
| *Valine |
640 mg |
|
** |
*Essential amino acids
**The U.S. RDI has not been established for this
nutrient.
†Ingredients with antioxidant properties or
ingredients that may nutritionally support antioxidant activity
D Conditionally
essential nutrients
Contraindications:
A history of previous sensitivity to any of the product's
ingredients. Any condition for which any of the ingredients in this
product are adverse or contraindicated. Any disease state managed by
pharmacotherapy for which alterations of serum drug levels secondary to
changes in hepatic metabolism could be life threatening.
Caution:
Excessive vitamin A intake may be toxic. Excess vitamin A intake may
increase the risk of birth defects. Pregnant women and women who may
become pregnant should not exceed 5000 IU total per day of pre-formed
vitamin A.
UltraClear SUSTAIN has not been tested in pregnancy, in
breastfeeding women, or in studies with children and, therefore, cannot be
recommended for use with these patients.
References:
- U.S. Patent number 4,876,096.
- Liska DJ, King M, Peterson B, Medcalf D. The
antigenicity of rice protein concentrate and rice flours. HealthComm
International, Inc. Research Report No. 102; in press.
- Juliano BO. Rice Chemistry and Technology. 2nd ed.
St. Paul, MI: The American Association of Cereal Chemists, Inc.;
1985:98-142.
- Goddard MS, Young G, Marcus, R. The effect of amylose
content on insulin and glucose responses to ingested rice. Am J Clin
Nutr. 1984;39:388-392.
- Miller JB, Pang E, Bramall L. Rice: a high or low
glycemic index food? Am J Clin Nutr. 1992;56:1034-1036.
- Salminen S, Isolauri E, Onnela T. Gut flora in normal
and disordered states. Chemotherapy. 1995;41(suppl 1):5-15.
- Midtvedt T, Carlstedt-Duke B, Høverstad T, et al.
Influence of peroral antibiotics upon the biotransformatory activity
of the intestinal microflora in healthy subjects. Eur J Clin Invest.
1986;16:11-17.
- Mitsuoka T, Hidaka H, Eida T. Effect of
fructo-oligosaccharides on intestinal microflora. Die Nahrung 31.
1987;5-6:427-436.
- Ko TC, Bèauchamp D, Townsend CM Jr., Thompson JC.
Glutamine is essential for epidermal growth factor-stimulated
intestinal cell proliferation. Surgery. 1993;114:147-154.
- Teran JC, Mullen KD, McCullough AJ. Glutamine - a
conditionally essential amino acid in cirrhosis? Am J Clin Nutr.
1995;62:897-900.
- Tahiliani AG, Beinlich CJ. Pantothenic acid in health
and disease. In: Vitamins and Hormones, Vol. 46. Academic Press, Inc;
1991:165-228.
- Lacroix B, Didier E, Grenier JF. Role of pantothenic
and ascorbic acid in wound healing processes: in vitro study on
fibroblasts. Int J Vit Nutr Res. 1988;58:407-413.
- Bornstein P, Byers PH. Disorders of collagen
metabolism. In: Bondy PK, Rosenberg LE, eds. Metabolic Control and
Disease. 8th Ed. W.B. Saunders Co.; 1980:1089-1153.
- Barrie S, Wright J, Pizzorno J, et al. Comparative
absorption of zinc picolinate, zinc citrate and zinc gluconate in
humans. Agents and Actions. 1987;21(1/2):2-7.
- De Luca LM, Darwiche N, Celli G, et al. Vitamin A in
epithilial differentiation and skin carcinogenesis. Nutr Rev.
1994;52(2):S45-S52.
- Packer L. Protective role of vitamin E in biological
systems. Am J Clin Nutr. 1991;53:1050S-1055S.
- Ketterer B, Coles B, Meyer DJ. The role of
glutathione in detoxification. Environ Health Perspectives.
1983;49:59-69.
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