Nutritional Information:
 What is UltraInflamX ?
UltraInflamX is a low-allergy-potential, nutritionally
fortified, vegetarian powdered beverage drink mix designed for nutritional support of
chronic inflammatory conditions of the lungs, joints, and intestinal tract. UltraInflamX
can be used as part of a comprehensive elimination or 4R™ diet program, as well as
nutritional support for patients involved in an anti-inflammatory lifestyle program.
UltraInflamX is a pleasant-tasting, easily digested and absorbed powdered beverage mix
formulated with a patented rice protein concentrate and augmented with the first and
second limiting amino acids (threonine and lysine) for increased biological value. This
protein concentrate is blended with high-molecular-weight rice dextrins as a carbohydrate
source. Medium-chain triglycerides and canola oil provide an excellent, easily absorbed
source of energy. UltraInflamX contains vitamins, minerals, and phytonutrients for
nutritional support of essential fatty acid metabolism, Phase II sulfation detoxification,
gastrointestinal mucosa integrity, and eduction of excessive free radical generation.
When blended in water, UltraInflamX provides a balanced supplement or meal replacement.
Who would benefit from using UltraInflamX ?
UltraInflamX provides nutritional support for conditions associated with chronic
inflammation. Individuals who suffer from the following symptoms or syndromes may benefit
from the nutritional support provided by UltraInflamX:
 | Inflammatory conditions of the intestinal tract, lungs, skin, or joints |
| Osteoarthritis |
| Rheumatoid arthritis |
| Immunologic or autoimmune dysfunction |
| Bronchial asthma |
Why should you use UltraInflamX?
| UltraInflamX is formulated from a rice protein concentrate made by a
special patented process that ensures consistent quality and lower allergy potential than
normal rice.1,2 UltraInflamX is free of dairy, lactose, gluten, wheat, yeast, soy, egg,
and artificial coloring or flavoring. |
| UltraInflamX contains enhanced levels of vitamins C, B3, B6, and the
minerals zinc and magnesium for nutritional support of essential fatty acid
metabolism.3,4,5 Imbalances in fatty acid metabolism have been implicated in the
generation of pro-inflammatory cytokines and prostaglandins.6,7,8 |
| UltraInflamX contains high levels of antioxidant vitamins and minerals
that may help reduce free radical generation. Free radicals have been implicated in a wide
variety of chronic inflammatory and degenerative processes.9,10 |
| UltraInflamX contains important nutrients such as vitamins B2, C, and A,
sodium sulfate, and N-acetylcysteine, and the minerals zinc, copper, and selenium, which
support Phase II detoxification pathways such as sulfation and glutathione
conjugation.11-13 Compromised sulfate-dependent detoxification has been associated with
inflammatory conditions such as rheumatoid arthritis and bronchial asthma.14,15 |
| UltraInflamX includes the phytonutrients curcumin, ginger, quercetin,
rutin, hesperidin, limonene, and rosemary to nutritionally support antioxidant and
anti-inflammatory activities.16-32 |
| UltraInflamX contains L-glutamine with vitamin B5, zinc, and quercetin
for nutritional support of gastrointestinal mucosa integrity.32-34 Inflammatory conditions
such as arthritis has been associated with intestinal dysfunction.35,36 |
How
to use UltraInflamX: Click title to access information
Features:
| 48 percent of calories from carbohydrate (blend of rice syrup solids and
rice protein concentrate) |
| 30 percent of calories from a patented rice protein concentrate augmented
with the first and second limiting amino acids for increased biological value |
| 22 percent of calories from fat as medium-chain triglycerides (MCT) and
canola oil |
| Mixes easily into water or juice |
| Does not contain gluten, wheat, corn, yeast, soy, egg, dairy, artificial
coloring, or artificial flavoring |
| 4 grams of low-allergy-potential fiber from rice bran |
Key Ingredients:
| Low-allergy-potential, fortified rice protein concentrate: The rice
protein concentrate is produced by a special patented process.1 It has been shown by
competition ELISA assays to be of lower allergy potential than normal rice.2 This patented
rice protein concentrate is fortified with the first and second limiting amino acids
threonine and lysine, resulting in a complete, high-quality, easily digestible vegetable
protein. |
| Vitamin A, mixed carotenoids, vitamin C, vitamin E, zinc, manganese, and selenium
act as antioxidants and are present in amounts above the RDA. Inflammation is associated
with increased free radical production. If not controlled adequately, free radicals can
react with polyunsaturated fatty acids of cell membranes and can lead to cellular damage.
Increased levels of antioxidants may protect against such injury.9,10 |
| N-acetylcysteine is an amino acid that contributes to glutathione
synthesis and protects against reactive oxygen species, such as hydrogen peroxide, which
can form lipid hydroperoxides. Aside from its role as an antioxidant, glutathione is an
important molecule in the detoxification and excretion of many xenobiotics and
metabolically produced oxidizing agents.13 |
| Curcumin is the yellow pigment and an active component in the spice
turmeric (Curcuma longa). Curcumin appears to have a variety of actions that make it a
potent anti-inflammatory agent, such as its ability to scavenge nitric oxide, act as an
antioxidant, inhibit synthesis of interleukin-1 and tumor necrosis factor, and inhibit
lipoxygenase and cyclooxygenase.16-18 Curcumin has also been shown to induce glutathione
production and glutathione-S-transferase activity, suggesting it may be beneficial in
conditions of impaired detoxification.19 Curcumin has been used clinically as an
anti-inflammatory for conditions such as postoperative inflammation, rheumatoid arthritis,
and osteoarthritis.20-22 |
| Rutin and its aglycone, quercetin, are antioxidants found in tea,
onions, and some citrus foods. Rutin and quercetin have been shown to act synergistically
with ascorbic acid and tocopherol in protection against oxidation injury, and they inhibit
the enzymes phospholipase A2, lipoxygenase, and cyclooxygenase, which produce
pro-inflammatory prostaglandins.23,24 Rutin and quercetin are well absorbed in the
intestine, and during absorption rutin may be converted to quercetin by removal of the
glycosidic moiety.25 |
| Rosemary (Rosmarinus officinalis) antioxidants have been shown to scavenge
inflammation-induced nitric oxide and peroxynitrite radicals, stimulate the phase II
detoxification activity of glutathione-S-transferase, and suppress DNA damage from
xenobiotics.26,27 |
| Limonene and hesperidin are bioflavonoids found in citrus foods.
Limonene induces the phase II detoxification glutathione and glucuronide conjugation.28
Hesperidin has been shown to contain analgesic and anti-inflammatory activity, which may
result from its ability to inhibit arachidonic acid metabolism and histamine release.29 |
| Ginger (Zingiber officinale) has been shown to be a potent inhibitor of
the synthesis of pro-inflammatory prostaglandins and thromboxanes.8 Ginger has been used
in the treatment of rheumatoid arthritis as well as osteoarthritis.30,31 |
| L-glutamine is a conditionally essential amino acid used by the
gastrointestinal tract mucosal cells (enterocytes) as preferred respiratory fuel.
L-glutamine supports the integrity of the GI mucosa barrier and may also be beneficial in
the prevention of bacterial translocation and intestinal inflammation.33,34 |
Ingredients:
Rice protein concentrate, rice syrup solids, rice bran fiber,rice bran
polishings, high oleic canola oil, medium-chain triglycerides, magnesium citrate, calcium
citrate, L-lysine hydrochloride, natural vanilla flavor, L-glutamine, dipotassium
phosphate, sodium ascorbate, curcumin, hesperidin powder, quercetin, rutin, D-alpha
tocopheryl acetate, dicalcium phosphate, N-acetylcysteine, citrulline, rosemary
antioxidants, d-limonene, ginger, sodium sulfate, xanthan, carageenan, cellulose gum, zinc
methionate (Opti-Zinc®), L-threonine, niacinamide, chromium polynicotinate, vitamin A
(mixed carotenoids, palmitate), manganese gluconate, selenomethionine,
pyridoxal-5'-phosphate, copper gluconate, calcium pantothenate, niacin, thiamin
hydrochloride, riboflavin, molybdenum amino acid chelate, vitamin D, folic acid, biotin,
and cyanocobalamin.
| Caloric Distribution |
Percent of Total Energy |
| Protein |
30% of calories |
| Carbohydrate |
48% of calories |
| Fat |
22% of calories |
| Nutritional Information |
Amount
2 Scoops |
%
U.S. RDI |
| |
(1 Serving) |
|
| Servings per container |
14 |
|
| Serving size |
52 g |
|
| Calories |
200 |
|
| Protein |
15 g |
|
| Carbohydrate |
24 g |
|
Complex
|
20 g |
|
Simple
|
4 g |
|
| Fat |
5 g |
|
| Cholesterol |
0 mg |
|
| Fiber |
4 g |
|
Vitamins:
| Nutritional Information |
Amount
2 Scoops |
%
U.S. rda |
| |
(1 Serving) |
|
| † Vitamin A (retinyl palmitate) |
2500 IU |
50% |
| † Beta-carotene |
2500 IU |
50% |
| Vitamin D |
100 IU |
25% |
| † Vitamin C (sodium ascorbate) |
180 mg |
300% |
| † Vitamin E (d-alpha tocopheryl acetate) |
100 IU |
330% |
| Vitamin B1(thiamin hydrochloride) |
2 mg |
130% |
| Vitamin B2 (riboflavin) |
2 mg |
120% |
| Niacin |
5 mg |
25% |
| Vitamin B3 (niacinamide) |
30 mg |
150% |
| Pantothenic acid (calcium pantothenate) |
5 mg |
50% |
| Vitamin B6 (pyridoxine hydrochloride) |
5 mg |
250% |
| Vitamin B12 (cyanocobalamin) |
3 mcg |
50% |
| Biotin |
150 mcg |
50% |
| Folic acid |
80 mcg |
20% |
Minerals and Trace Elements:
| Nutritional Information |
Amount
2 Scoops |
%
U.S. rda |
| |
(1 Serving) |
|
| Sodium |
100 mg |
|
| Potassium (phosphate) |
400 mg |
|
| Calcium (citrate) |
275 mg |
25% |
| Iron (ferrous fumarate) |
1 mg |
5% |
| Phosphorous |
200 mg |
20% |
| Magnesium (citrate) |
280 mg |
70% |
| †Zinc (methionate) |
10 mg |
70% |
| †Copper (gluconate) |
1 mg |
50% |
| †Manganese (gluconate) |
2 mg |
100% |
| Molybdenum (amino acid chelate) |
38 mcg |
50% |
| Chromium (ChromeMate® GTF) |
60 mcg |
50% |
| †Selenium (selenomethionine) |
75 mcg |
105% |
Accessory Nutrients:
| Nutritional Information |
Amount
2 Scoops |
%
U.S. rda |
| |
(1 Serving) |
|
| D
†N-acetylcysteine |
100 mg |
** |
| D
†L-glutamine |
750 mg |
** |
| L-threonine |
490 mg |
** |
| L-lysine hydrochloride |
1210 mg |
** |
| Citrulline |
100 mg |
** |
| Hesperidin powder |
200 mg |
** |
| D-Limonene |
100 mg |
** |
| †Rutin |
200 mg |
** |
| Ginger |
100 mg |
** |
| †Quercetin |
200 mg |
** |
| †Curcumin |
200 mg |
** |
| †Rosemary antioxidants |
100 mg |
** |
| Sodium sulfate |
50 mg |
** |
Typical Amino Acid Profile:
| Nutritional Information |
Amount
2 Scoops |
%
U.S. rda |
| |
(1 Serving) |
|
| Alanine |
710 mg |
** |
| Arginine |
1190 mg |
** |
| Aspartic acid |
1140 mg |
** |
| Cystine |
280 mg |
** |
| Glutamic acid |
2130 mg |
** |
| Glycine |
590 mg |
** |
| Histidine |
300 mg |
** |
| *Isoleucine |
530 mg |
** |
| *Leucine |
1090 mg |
** |
| *Lysine |
1210 mg |
** |
| *Methionine |
300 mg |
** |
| *Phenylalanine |
650 mg |
** |
| Proline |
660 mg |
** |
| Serine |
710 mg |
** |
| *Threonine |
490 mg |
** |
| *Tryptophan |
160 mg |
** |
| Tyrosine |
670 mg |
** |
| *Valine |
590 mg |
** |
*Essential amino acids
**The U.S. RDI has not been established for this nutrient.
†Ingredients with antioxidant properties or ingredients that may nutritionally
support antioxidant activity
D Conditionally essential nutrients
OptiZinc® is a registered trademark of InterHealth Company.
Contraindications:
A history of previous sensitivity to any of the product’s
ingredients. Any condition for which any of the ingredients in this product are adverse or
contraindicated. Any disease state managed by pharmacotherapy for which alterations of
serum drug levels secondary to changes in hepatic metabolism could be life threatening.
Caution:
Excessive vitamin A intake may be toxic. Excess vitamin A intake may
increase the risk of birth defects. Pregnant women and women who may become pregnant
should not exceed 5,000 IU total per day of pre-formed vitamin A.
UltraInflamX has not been tested in pregnancy, in breastfeeding women,
or in studies with children and, therefore, cannot be recommended for use with these
patients.
References:
- U.S. Patent number 4,876,096.
- Liska DJ, King M, Peterson B, Medcalf D. The antigenicity of rice protein
concentrate and rice flours. HealthComm International, Inc. Research Report No. 102.
1997; pp. 1-9.
- Mahfouz MM, Kummerow FA. Effect of magnesium deficiency on delta 6
desaturase activity and fatty acid composition of rat liver microsomes. Lipids.
1989;24(8):727-732.
- Mahfouz MM, Smith TL, Kummerow FA. Changes of linoleic acid metabolism
and cellular phospholid fatty acid composition in LLC-PK cells cultured at low magnesium
concentrations. Biochim Biophys Acta. 1989;1006(1):70-74.
- Cunnane SC. Differential regulation of essential fatty acid metabolism to
the prostaglandins: possible basis for the interaction of zinc and copper in biological
systems. Prost Lipid Res. 1982;21:73-89.
- Carmichael HA. Use of nutritional precursors of prostaglandin E1 in the
management of rheumatoid arthritis and chronic coxsackie infection. In: Horrobin DF, ed. Clinical
Uses of Essential Fatty Acids. Eden Press;1982:139-146.
- Lindahl M, Tagesson C. Flavonoids as phopholipase A2 inhibitors:
Importance of their structure for selective inhibition of group II phospholipase A2. Inflammation.
1997;21(3):347-356.
- Kiuchi F, Shiuyu M, Sankawa U. Inhibitors of prostaglandin biosynthesis
from ginger. Chem Pharm Bull. 1982;30:754-757.
- Moslen MT. Protection against free radical-mediated tissue injury. In:
Free Radical Mechanisms of Tissue Injury. Boca Raton, FL: CRC Press; 1992:204-213.
- Maxwell SRJ. Prospects for the use of antioxidant therapies. Drugs.
1995;49:345-361.
- Anderson KE, Kappas A. Dietary regulation of cytochrome P450. Ann Rev
Nutr. 1991;11:141-167.
- Levy G. Sulfate conjugation in drug metabolism: role of inorganic
sulfate. Federation Proc. 1986;45:2235-2240.
- Yim CY, Hibbs JB Jr, McGregor JR, Galinsky RE, Samlowski WE. Use of
N-acetyl cysteine to increase intracellular glutathione during the induction of antitumor
responses by IL-2. J Immunol. 1994;152:5796-5805.
- Bradley H, Waring RH, Emery P, Arthur V. Metabolism of low-dose
paracetamol in patients with rheumatoid arthritis. Xenobiotica. 1991;21:689-693.
- Scoggan KA, Jakobsson PJ, Ford Hutchinson AW. Production of leukotriene
C4 in different human tissues is attributable to distinct membrane bound biosynthetic
enzymes. J Biol Chem. 1997;272:10182-10187.
- Sreejayan, Rao MNA. Nitric oxide scavenging by curcuminoids. J Pharm
Pharmacol. 1997;49:105-107.
- Chan MM-Y. Inhibition of tumor necrosis factor by curcumin, a
phytochemical. Biochem Pharmacol. 1995;11:1551-1556.
- Huang M-T, Lysz T, Ferraro T, Abidi TF, Laskin JD, Conney AH. Inhibitory
effects of curcumin on in vitro lipoxygenase and cyclooxygenase activities in mouse
epidermis. Cancer Res. 1991;51:813-819.
- Susan M, Rao MNA. Induction of glutathione S-transferase activity by
curcumin in mice. Drug Res. 1992;42(7):962- 964.
- Satoskar RR, Shah SJ, Shenoy SG. Evaluation of anti-inflammatory property
of curcumin (diferuloyl methane) in patients with postoperative inflammation. International
J Clin Pharmacol Therapy Toxicol. 1986;24:651-654.
- Deodhar SD, Sethi R, Srimal RC. Preliminary study on anti-rheumatic
activity of curcumin (diferuloyl methane). Ind J Med Res. 1980;71(12):632-634.
- Kulkarni RR, Patki PS, Jog VP, et al. Treatment of osteoarthritis with a
herbomineral formulation: a double-blind, placebo-controlled, crossover study. J
Ethnopharmacol. 1991;33:91-95.
- Negre-Salvayre A, Affany A, Hariton C, Salvayre R. Additional
antilipoperoxidant activities of alpha-tocopherol and ascorbic acid on membrane-like
systems are potentiated by rutin. Pharmacol. 1991;42:262-272
- Skaper SD, Fabris M, Ferrari V, Carbonare MD, Leon A. Quercetin protects
cutaneous tissue-associated cell types including sensory neurons from oxidative stress
induced by glutathione depletion: cooperative effects of ascorbic acid. Free Rad Biol
Med. 1997;22(4):669-678.
- Hollman P CH, de Vries JHM, van Leeuwen SD, Mengelers MJB, Katan MB.
Absorption of dietary quercetin glycosides and quercetin in healthy ileostomy volunteers. Am
J Clin Nutr. 1995;62:1276-1282.
- Chan MM-Y, Ho C-T, Huang H-I. Effects of three dietary phytochemicals
from tea, rosemary and tumeric on inflammation-induced nitrite production. Cancer Lett.
1995;96:23-29.
- Offord EA, Mace K, Avanti O, Pfeifer AMA. Mechanisms involved in the
chemoprotective effects of rosemary extract studied in human liver and bronchial cells. Cancer
Lett. 1997;114:275-281.
- Elegbede JA, Maltzman TH, Elson CE, Gould MN. Effects of anticarcinogenic
monoterpenes on phase II hepatic metabolizing enzymes. Carcinogenesis.
1993;14(6):1221-1223
- Emim JADS, Oliveira AB, Lapa AJ. Pharmacological evaluation of the
anti-inflammatory activity of a citrus bioflavonoid, hesperidin, and the isoflavonoids,
duartin and claussequinone, in rats and mice. J Pharm Pharmacol. 1994;46:118-122.
- Srivastava KC, Mustafa T. Ginger (Zingiber officinale) in rheumatisim and
musculoskeletal disorders. Med Hypotheses. 1992;39:342-348.
- Srivastava KC, Mustafa T. Ginger (Zingiber officinale) and rheumatic
disorders. Med Hypotheses. 1989;29:25-28.
- Alarcon de la Lastra C, Martin MJ, Motilva V. Antiulcer and
gastroprotective effects of quercetin: a gross and histological study. Pharmacology.
1994;48:56-62.
- Souba WW. Glutamine: a key substrate for the splanchnic bed. Annu Rev
Nutr. 1991;11:285-308
- Fujita T, Sakurai K. Efficacy of glutamine-enriched enteral nutrition in
an experimental model of mucosal ulcerative colitis. British J Surgery. 1995;82:749-751.
- Lichtman SN, Wang J, Sartor RB, et al. Reactivation of arthritis induced
by small bowel bacterial overgrowth in rats: role of cytokines, bacteria, and bacterial
polymers. Infect Immunity. 1995;63:2295-2301.
- Hazenberg MP. Intestinal flora bacteria and arthritis: why the joint? Scand
J Rheumatol. 1995;24:207-211.
|
UltraInflamX